A real interesting article entitled “A non-invasive digital biomarker for the detection of rest disturbances in the SOD1G93A mouse model of ALS” and published by Frontiers in Neuroscience, section Sleep and Circadian Rhythms, described the idea to use the DVC® system to capture irregular activity patterns that can potentially be associated with sleep and rest disturbances and thus to the progression of ALS in the SOD1G93A mouse model.
DVC® has been selected because this system enables non-intrusive 24/7 long term animal activity monitoring, which we assessed together with body weight decline and neuromuscular function deterioration measured by grid hanging and grip strength tests in male and female mice from 7 until 24 weeks of age.
The results of the study underline how the non-intrusive long-term continuous monitoring of animal activity enabled by DVC® has been instrumental in discovering novel activity patterns potentially correlated, once validated, with sleep and rest disturbances in the SOD1G93A mouse model of the ALS disease.
If you want to read this interesting and exciting article click here
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